Description
Unlocking the Hidden History of DNA course. Locked within the DNA of every species that has ever lived are endless stories about origins, ancestry, destiny, and much more. Until recently, these secrets were completely inaccessible. But with the help of new technologies, scientists are now reading the hidden history of DNA and making remarkable discoveries about our past. DNA not… Below are the comments of some users:
“The operative word in the title is *date*. This lesson is the history of science. Therefore, it is more anecdotal than technical, although anecdotes are about technical events. This course is a series of twelve lectures on the *history* of discoveries in genetics. There is almost as much debate about the politics of scientific discovery, funding, and credit as there is about technical discovery itself. The history begins with Gregor Mendel and his peas in the 19th century, continues through the discovery of DNA in the 20th century, and ends with the discussion of epigenetics today. Mr. Kane (does not have a doctorate) is a writer and neither a professor nor a researcher. He communicates well (as one would expect from an author) including communicating the basics of genetics. He makes good use of graphics to reinforce his points. The course guide is above average by The Great Courses (TGC) standards. Written in paragraph form (as opposed to outline or bullet format). There are over 10 pages per lecture, which is more than most TGC course guides. However, few useful graphics are embedded in the lectures. Appendices include a multiple-choice quiz (thankfully, with an answer key) and a bibliography detailing the value each reference provides. It is strange that there is no glossary for such a technical subject as genetics. Perhaps even more oddly, there are no biographical notes, which one might expect for a course so heavily focused on *history*. I used the audio version. While most of the speech simply featured Mr. Keane talking and most of the graphics were pictures of historical figures, there were some important technical graphics as well. “Simply listening to lectures while jogging or commuting loses content.”
“This course was one of the most interesting courses I watched. Additionally, it struck a good balance between providing background and building on the prior knowledge presented. While it’s been years since high school biology and chemistry, the background needed to understand the presentation was minimal. However, the topic was not “tricky”, it was just presented in a way to understand the concepts without trying to learn. The speaker was dynamic and easy to listen to. The graphics were very helpful in illustrating his points.”
“The first course and The Hidden History of DNA were both great. I learned things that I never had in my previous high school or college life in biology. Now I understand more by reading or hearing articles about DNA. The professors are both top notch, although I would like Stephen Nowicki to slow down a bit. All information is new and it’s not easy to get it, go around first.”
Kane’s 2020 range begins with a bright caution: “Whatever we know or think we know about DNA, our knowledge is often closely related to how we discover it.” In the 70’s we were told (as Lecture 6 (=L6) states) that most DNA is non-coding and therefore “junk” DNA. However, in the 1970s, entanglement theory stated that complex systems (such as DNA) have multiple simultaneous initial conditions that dynamically change to solutions that are finite only for a particular moment in time (see Strugatz’s great “chaos” period There should be little or no “junk.” L6 reinforces the view that the 22 amino acids or 4 letters of DNA contain genetic information. The DNA code was misrepresented because the rough DNA extraction methods in those experiments (L2) contained radioactive phosphorus in the other protein Individual petri dishes containing the bacteria were poured in. After the T2 had adhered to the bacteria, they separated each solution with a kitchen blender and separated the bacteria by centrifugation containing phosphorus and none found in the protein/sulfur solution.I remember the T2 test from my father’s texts studying for his Ph.D. L2/L3 elevates Rosalind Franklin, whose observations of how the DNA phosphate backbone binds sometimes to water and sometimes to water loss led to the important photo 51 (of X-rays reflected from DNA on film) that a “ presented a two-dimensional image. Extrapolation to different 3D. An intermediary (Wilkins) who was jealous of his abilities showed this to Watson and Crick, who were building a “tinker-toy” model of chemical DNA. This confirmed Watson’s idea that DNA is a helix. But their model ignored the Franklin interactions of water and phosphate. By the time Chargaff proved that adenine and thiamine/cytosine and guanine always paired, a double helix with its bases in the center (and phosphates on the outside as Franklin had predicted) showed Watson/Crick how DNA worked. he does. L4: Genes coding for proteins are rarely subject to lethal “frameshift mutations” (adding or deleting a letter). Genes are further apart and the “non-coding” DNA between them is more susceptible to mutation and inheritance. The “satellite repeats” of DNA base triplets do not appear to be functional but contribute to DNA fingerprinting (L6) and lineage (L10). L6: More than 80% of non-protein-coding “junk DNA” is transcribed into RNA. Here Kane begins to describe how genes drive, and are sometimes driven by, culture: “Nature and nurture work together to make us what we are.” Each of us is a special creation according to the Bible and according to our “non-coding DNA”. He then discusses the effects of the intelligence/language gene FOXP2, where we found 2 or 3 amino acid changes after isolation from great apes that allow FOXP2 to interact with new genes. Gene splicing, where cells “decide” what to cut out of the RNA copy to remove introns and keep exons, is an example with the protein that connects muscle to other tissues. 14,000 exons are separated from 2.2 million introns in a 16-hour process! What’s more: Our brain cells cut and edit basic strands for far more varied effects than other primates, allowing “jump genes” to provide neural diversity. Regarding microbe manipulation, L7 states that “mobile genetic elements” are sometimes useful for gene regulation or may cause viruses. As you can imagine, we are now into Chaos Theory, and L12 is warning that “personalized medicine” DNA modification is about to happen. It will definitely lead to unintended consequences.” L8 “covers DNA as the hardware, while epigenetics is the software that uses methyl groups or histones (chromosomal protein coils) that can turn genes on or off. Epigenetics explains why identical twins differ over time and how cocaine and heroin can permanently damage DNA. For those who want to go to Mars: 6 months after astronaut Scott Kelly’s twin spent a year in space, his epigenetics has been resolved in “all but 800 genes.” Important: Most epigenetic changes appear to be erased after conception, except for male epigenetics, which are acquired between ages 9 and 12. L10: Y Gene Test Shows Genghis Khan’s Dynasty Shows Continued Abuse of Women (The Great Era of “Steppe Barbarians”_Harrell) Links 16 Men as His Children Today Summary: Cain’s Brilliant Era is a summary of many of the things we To what extent have we moved away from the view of “junk DNA”?
What you will learn in the Unlocking the Hidden History of DNA course
- Learn how scientists can look deep into the DNA molecule to reveal lost stories about our origins, ancestors, and cultural milestones.
- The science of genetics traces back to Gregor Mendel’s pioneering experiments with pea plants in the mid-19th century
- Review of the “Manhattan Project” DNA: The Human Genome Project to sequence all three billion base pairs of human genetic material
- Look to the future of DNA science to see surprising and controversial techniques like CRISPR that are reshaping our genomes, for better or worse.
Details of the Unlocking the Hidden History of DNA course
- Publisher: Thegreatcrosses
- teacher: Sam Kean
- Education level: Intermediate
- Training duration: 3 hours
- Number of courses:
The headings of the Unlocking the Hidden History of DNA course
Course images
Sample video of the course
Installation guide
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Quality: 720p
download link
File(s) password: www.downloadly.ir
Size
5.47 GB
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